Lipids make smooth brains gyrate.
نویسنده
چکیده
The surface area of the cerebral cortex has increased massively during mammalian evolution and this change has been accompanied by folding of the cortical sheet into gyri. The molecular mechanisms that control cortical size are poorly understood. A recent study suggests that the regulation of cortical size might involve phospholipids, by showing that their addition to cultured embryonic mouse cortices increases cortical size and induces folds resembling gyri.
منابع مشابه
Near-infrared spectrophotometric monitoring of stroke-related changes in the protein and lipid composition of whole gerbil brains.
Strokes are a critical problem in the U.S. that affect more than 500,000 people annually. Research into the causes of stroke and testing of drug therapies to reduce ischemic and postischemic damage to the brain is frustrated by an inability to continuously follow the physical and chemical events that occur during ischemia and reperfusion in vivo. Near-IR spectrometry is used in this paper to ob...
متن کاملRetinal detachment and gyrate atrophy of the choroid and retina: case report.
To report a case of gyrate atrophy of the choroid and retina associated with retinal detachment. Hyperornithinemia confirmed the diagnosis of gyrate atrophy. Pars plana vitrectomy with silicone oil infusion was performed with good anatomical results, despite the persistence of low visual acuity. Retinal detachment is a rare complication of gyrate atrophy and can be managed with pars plana vitre...
متن کاملGyrate Atrophy of the Choroid and Retina: A Case Report
Introduction Gyrate atrophy of the choroid and retina is a metabolic disorder, which is inherited in an autosomal recessive pattern. Although gyrate atrophy is rare, it is concerning as it results in blindness. It is characterized by hyperornithinemia, retinal atrophy, leads to progressive myopia and tunnel vision,...
متن کاملCataract in gyrate atrophy: clinical and morphologic studies.
The clinical appearance of the cataract in nine phakic patients with gyrate atrophy of the choroid and retina is described. The gross and microscopic examination of three cataractous lenses removed from patients 31 years to 47 years of age is reported. Clinically, the lens opacities appeared primarily along the confluence of the sutures posteriorly, interfering with vision because of their loca...
متن کاملA rare ophthalmologic disorder: Gyrate atrophy with sparse hair
Gyrate atrophy (GA) is a rare, progressive metabolic choroid and retinal degeneration that results from a deficiency of the pyridoxal phosphate-dependent mitochondrial matrix enzyme ornithine aminotransferase. Here, we report the case of a 40-yearold woman who presented with a gradual decline in visual acuity since puberty, along with a history of high myopia and cataract surgery. She was admit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Trends in neurosciences
دوره 27 7 شماره
صفحات -
تاریخ انتشار 2004